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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Role of TRP channels in the cardiovascular system

Zhichao Yue1, Jia Xie1, Albert S Yu1

  • 1Calhoun Cardiology Center, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut.

American Journal of Physiology. Heart and Circulatory Physiology
|November 23, 2014
PubMed

Insights

Transient Receptor Potential (TRP) channels are crucial for cardiovascular function, sensing various stimuli to regulate cell activity. Their dysfunction contributes to cardiovascular diseases, highlighting their potential as therapeutic targets.

Area of Science:

  • Cardiovascular Physiology
  • Ion Channel Biology
  • Molecular Medicine

Background:

  • Transient Receptor Potential (TRP) channels form a superfamily of nonselective cation channels with diverse Ca(2+)-permeability.
  • Mammalian TRP channels, grouped into six subfamilies, are expressed in cardiovascular cells and sense mechanical, chemical, and stress stimuli.
  • TRP channels integrate multiple signals, influencing cell functions like contraction and proliferation via Ca(2+) entry and depolarization.

Purpose of the Study:

  • To review the physiological roles of TRP channels in the cardiovascular system.
  • To explore the involvement of TRP channels in cardiovascular disease pathophysiology.
  • To identify TRP channels as potential therapeutic targets for cardiovascular conditions.

Main Methods:

  • Literature review of current knowledge on TRP channel function and disease relevance.
  • Analysis of studies utilizing targeted deletion and transgenic mouse models.
  • Synthesis of findings on TRP channel involvement in cardiovascular pathophysiology.

Main Results:

  • TRP channels regulate fundamental cardiovascular cell functions, including contraction, relaxation, proliferation, differentiation, and cell death.
  • TRP channel dysfunction is implicated in the pathophysiology of numerous cardiovascular diseases.
  • Several TRP channels are associated with inherited cardiovascular diseases.

Conclusions:

  • TRP channels are vital regulators of cardiovascular physiology and disease.
  • Understanding TRP channel mechanisms offers new avenues for treating cardiovascular disorders.
  • TRP channels represent promising therapeutic targets for cardiovascular diseases.
Keywords:
Ca2+ signalingTRP channelsheart diseasespathogenesisvascular disorders

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