Related Experiment Video
Updated: Apr 20, 2026
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
Published on: November 22, 2017
Monitoring mitophagy in mammalian cells
Yushan Zhu1, Guo Chen1, Linbo Chen1
1State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, China.
Abstract:
It is essential for a cell to maintain a proper mitochondrial quality and quantity for normal cellular functions. Damaged or unwanted mitochondria can be selectively removed through mitophagy. Mitophagy research has attracted great attention from life sciences and biomedical fields, it is thus important for the community to properly measure mitophagy. Here, we will focus on the current techniques that have been used to monitor mitophagy in mammalian cells, including morphological and biochemical parameters for monitoring the occurrence of mitophagy.
More Related Videos
Related Concept Videos
01:19Translocation of Proteins into the Mitochondria
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
01:27Autophagy
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...