Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

10.6K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.6K
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

557
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
557
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

398
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
398
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

1.3K
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteo-metabolomic insights into the progression of chronic obstructive pulmonary disease and lung function decline.

Respiratory research·2026
Same author

The relationship between traditional Chinese medicine constitution and indexes in chronic obstructive pulmonary disease patients: a systematic review and network meta-analysis.

Frontiers in medicine·2026
Same author

Strain analysis based on dynamic ventilation computed tomography in fibrotic interstitial lung disease and its correlation with pulmonary function tests.

Quantitative imaging in medicine and surgery·2026
Same author

Quantitative label-free multiphoton imaging of collagen features predicts disease severity and progression in idiopathic pulmonary fibrosis.

Respiratory research·2026
Same author

Silencing core circadian regulators CLOCK and BMAL1 inhibits autophagy in interstitial cells of Cajal in a gastroesophageal reflux disease model.

Immunobiology·2026
Same author

10 years trends and hospitalization outcomes of non-neonatal tetanus: a large-scale multicenter retrospective study in China.

Critical care (London, England)·2026
Same journal

Clinical Europium fluorescent based lectin assays for mucin O-glycomics.

Methods in enzymology·2026
Same journal

A dual-color FRET assay for detection and quantitative analysis of O-glycopeptidases.

Methods in enzymology·2026
Same journal

Evolutionary genetic approaches to analyze mucins.

Methods in enzymology·2026
Same journal

Ex vivo imaging and enzymatic analysis of intestinal mucus.

Methods in enzymology·2026
Same journal

Glyco-TRAPP: A real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues.

Methods in enzymology·2026
Same journal

Quantitative imaging approaches to capture structural and functional dynamics of colonic mucus in health and disease in situ.

Methods in enzymology·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.2K

MR OEF imaging in MELAS.

Sheng Xie1

  • 1Department of Radiology, China-Japan Friendship Hospital, BeiJing, China.

Methods in Enzymology
|November 23, 2014
PubMed
Summary
This summary is machine-generated.

Oxygen extraction fraction (OEF) imaging reveals reduced oxygen utilization in MELAS patients. This quantitative MRI method highlights mitochondrial dysfunction in stroke-like lesions and normal-appearing brain regions, offering insights into disease mechanisms.

Keywords:
Blood-oxygen-level dependentCerebral blood flowGradient-echo sampling of spin echoMRIMitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodesOxygen extraction fractionStroke-like episode

More Related Videos

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.3K
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.5K

Related Experiment Videos

Last Updated: Apr 20, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.2K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.3K
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.5K

Area of Science:

  • Neuroimaging
  • Mitochondrial Biology
  • Cerebrovascular Medicine

Background:

  • Oxygen extraction fraction (OEF) quantifies tissue oxygen utilization, serving as a key hemodynamic marker in brain ischemia.
  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disorder characterized by neurological relapses and cognitive decline.
  • Reduced cerebral oxygen utilization due to mitochondrial dysfunction in MELAS leads to decreased OEF.

Purpose of the Study:

  • To investigate the utility of quantitative OEF imaging in patients with MELAS.
  • To assess cerebral mitochondrial function and pathophysiological changes in the brain using OEF.
  • To explore the relationship between OEF changes and stroke-like episodes in MELAS.

Main Methods:

  • Development of a novel gradient-echo sampling of spin echo MR sequence for quantitative OEF imaging.
  • Application of MR OEF imaging in patients diagnosed with MELAS.
  • Analysis of OEF values in stroke-like lesions and normal-appearing brain regions.

Main Results:

  • MR OEF imaging detected significant OEF reduction in both stroke-like lesions and normal-appearing brain regions in MELAS patients.
  • Greater OEF reduction in stroke-like lesions suggests more severe mitochondrial dysfunction at episode onset.
  • Chronological OEF determination revealed dynamic changes in mitochondrial function during stroke-like episodes.

Conclusions:

  • Quantitative MR OEF imaging is a valuable tool for assessing cerebral mitochondrial function in MELAS.
  • OEF imaging provides insights into the pathophysiology of stroke-like episodes in MELAS.
  • This neuroimaging technique may aid in understanding the underlying mechanisms of MELAS-related neurological events.