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Updated: Apr 20, 2026

Scalable Step-by-Step Approach of Sustainable Bioplastic Production from Food Waste
Published on: July 18, 2025
An integrated biotechnology platform for developing sustainable chemical processes
Nelson R Barton1, Anthony P Burgard, Mark J Burk
1, Genomatica, Inc., 4757 Nexus Center Drive, San Diego, CA, 92121, USA.
Abstract:
Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.
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