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Fleroxacin resistance in Escherichia coli
J S Chapman1, A Bertasso, N H Georgopapadakou
1Roche Research Center, Nutley, New Jersey 07110.
Antimicrobial Agents and Chemotherapy
|February 1, 1989
Abstract:
Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.