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Estimated GFR or albuminuria: which one is really associated with resistant hypertension?
César A Romero1, Aldo J Peixoto2, Marcelo Orias3
1Hospital Privado, Córdoba, Argentina; Instituto de Investigación Médica "Mercedes y Martin Ferreyra," INIMEC-CONICET, Córdoba, Argentina.
Abstract:
Patients with resistant hypertension belong to a very high cardiovascular risk group and have a high prevalence of target organ damage. Microalbuminuria and low estimated glomerular filtration rate are associated with resistant hypertension, and could be a cause and/or complication of hypertension. In this review, we explore the relationship between these 2 markers of kidney disease and the prevalence of resistant hypertension. We identified different phenotypes of resistant hypertension that associate with microalbuminuria and/or low estimated glomerular filtration rate. These phenotypes suggest that high sympathetic activity associated with fluid overload and endothelial dysfunction may contribute differently to the development of resistant hypertension.
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