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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

7.0K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Related Experiment Video

Updated: Apr 20, 2026

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
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Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

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Notch signaling and ageing.

Eleftheria Polychronidou1, Dimitrios Vlachakis, Panayiotis Vlamos

  • 1Bioinformatics and Medical Informatics Team, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens, 11527, Greece.

Advances in Experimental Medicine and Biology
|November 24, 2014
PubMed
Summary
This summary is machine-generated.

Notch signaling regulates brain development and function. While crucial for normal brain activity, Notch mutations are linked to neurodegenerative diseases like Alzheimer's, highlighting its complex role.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Notch signaling is a critical regulator of neural stem cell differentiation and neural development.
  • It plays a vital role in normal brain function, embryogenesis, and various physiological processes.
  • Notch pathway dysregulation is implicated in neurodegenerative conditions, including Alzheimer's disease, Down syndrome, and CADASIL.

Purpose of the Study:

  • To provide a comprehensive overview of Notch signaling's dual role in the adult brain.
  • To elucidate both the beneficial and detrimental contributions of Notch signaling.
  • To identify and promote emerging research avenues within this field.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies investigating Notch signaling in neural development and disease.
  • Identification of key findings on Notch pathway involvement in adult brain function and pathology.

Main Results:

  • Notch signaling is essential for maintaining normal adult brain function and development.
  • Mutations or alterations in Notch signaling are associated with increased risk and progression of neurodegenerative diseases.
  • The precise impact of Notch signaling varies depending on context, cell type, and specific mutations.

Conclusions:

  • Notch signaling presents a complex, context-dependent role in the adult brain.
  • Understanding its multifaceted contributions is crucial for developing therapeutic strategies for neurodegenerative disorders.
  • Further research into Notch signaling pathways holds significant promise for future neuroscience advancements.