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Related Experiment Video

Updated: Apr 20, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

Time in motion: the molecular clock meets the microbiome.

Xue Liang¹, Frederic D Bushman², Garret A FitzGerald¹

¹Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

|November 24, 2014

Summary

The gut microbiome fluctuates daily, influenced by when we eat. Disrupting the body

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Related Experiment Videos

Last Updated: Apr 20, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

Microbiology
Chronobiology
Metabolic Health

Background:

The intestinal microbiota exhibits daily rhythms.
Host feeding schedules regulate these microbial oscillations.
Circadian clock disruption is linked to gut dysbiosis.

Purpose of the Study:

To investigate the relationship between host feeding time and intestinal microbiota diurnal oscillations.
To explore the consequences of circadian clock disruption on gut microbial composition and host metabolism.

Main Methods:

Analysis of intestinal microbiota composition.
Monitoring of host circadian rhythms.
Assessment of host metabolic parameters.

Main Results:

Host feeding time dictates the diurnal oscillation patterns of the intestinal microbiota.
Disruption of the host circadian clock leads to significant gut dysbiosis.
Induced dysbiosis is associated with the development of host metabolic disorders.

Conclusions:

Host feeding schedules are critical regulators of intestinal microbiota daily rhythms.
Circadian disruption negatively impacts gut microbial ecology and host metabolic health.
Targeting feeding times may offer a strategy to manage gut dysbiosis and metabolic disorders.