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Updated: Apr 20, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Extrapulmonary manifestations of community acquired pneumonia]
Abstract:
The key diagnostic features of community acquired pneumonia are sometimes mixed with extrapulmonary clinical manifestations which are important to recognize. Indeed, when present, these clinical clues can help tailor the diagnostic and therapeutic approach in a more specific way. For example, the presence of diarrhea, acute confusion and hyponatremia are suggestive of Legionella pneumophila, and therefore this pathogen needs to be included in the initial antibiotic regimen. Extrapulmonary manifestations are sometimes difficult to distinguish from septic complications of the pneumonia, but can sometimes warrant a specific treatment. The goal of this review is to remind the reader of the broad spectrum of these manifestations and their association with specific pathogens, most often the "atypical" ones.
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