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Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
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Markers of pancreatic function in the breath
Kiera Roberts1, Ivan Liu, Adam Jaffe
1Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Journal of Breath Research
|November 25, 2014
Summary
Exhaled breath condensate analysis revealed higher C-peptide levels in children with cystic fibrosis (CF) and diabetes mellitus (DM). This finding may indicate airway inflammation rather than increased pancreatic secretion.
Area of Science:
- Biomarkers
- Respiratory Medicine
- Endocrinology
Background:
- Exhaled breath analysis can detect biomarkers for various diseases.
- Pancreatic function markers in breath are not well-established for conditions like diabetes mellitus and cystic fibrosis.
Purpose of the Study:
- To investigate the presence of pancreatic function markers in the exhaled breath condensate (EBC) of children with diabetes mellitus (DM), cystic fibrosis (CF), and cystic fibrosis-related diabetes (CFRD).
Main Methods:
- Collected EBC from 104 children (aged 6-18) with DM, CF, CFRD, and healthy controls.
- Measured C-peptide, glucose, sodium, and conductivity in EBC.
- Concurrent blood glucose measurements were taken from a subset.
Main Results:
- C-peptide was significantly higher in the EBC of children with CF, DM, and CFRD compared to controls (p < 0.0001).
- No significant differences in EBC glucose, conductivity, or sodium were observed between groups.
- Glucose was not reliably detected in EBC.
Conclusions:
- Elevated C-peptide in EBC of CF and DM patients may reflect airway inflammation and altered integrity, not necessarily increased pancreatic secretion.
- Further research is needed to validate EBC C-peptide as a biomarker for pancreatic function in these conditions.
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