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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
A review of dengue research in malaysia
W K Cheah1, K S Ng2, A R Marzilawati2
1Hospital Taiping, Department of Medicine, 34000 Perak, Malaysia. drcheah.moh@1govuc.gov.my.
Abstract:
Dengue infection is a major cause of morbidity and mortality in Malaysia. To date, much research on dengue infection conducted in Malaysia have been published. One hundred and sixty six articles related to dengue in Malaysia were found from a search through a database dedicated to indexing all original data relevant to medicine published between the years 2000-2013. Ninety articles with clinical relevance and future research implications were selected and reviewed. These papers showed evidence of an exponential increase in the disease epidemic and a varying pattern of prevalent dengue serotypes at different times. The early febrile phase of dengue infection consist of an undifferentiated fever. Clinical suspicion and ability to identify patients at risk of severe dengue infection is important. Treatment of dengue infection involves judicious use of volume expander and supportive care. Potential future research areas are discussed to narrow our current knowledge gaps on dengue infection.
Insights
This review highlights the increasing dengue fever epidemic in Malaysia, emphasizing the need for early clinical suspicion and supportive care. Future research should address knowledge gaps in dengue infection management and prevention.
Area of Science:
- Medical Research
- Epidemiology
- Infectious Diseases
Background:
- Dengue infection is a significant public health concern in Malaysia, contributing to substantial morbidity and mortality.
- A review of Malaysian dengue research published between 2000-2013 was conducted to understand disease trends and clinical implications.
Purpose of the Study:
- To analyze the trends and patterns of dengue infection in Malaysia based on published literature.
- To identify clinical relevance and future research directions for dengue infection in the region.
Main Methods:
- A comprehensive literature search was performed using a medical database for articles published from 2000 to 2013.
- One hundred and sixty-six articles on dengue in Malaysia were identified, and 90 relevant articles were selected for review.
Main Results:
- The reviewed literature indicates an exponential increase in the dengue epidemic in Malaysia.
- A variable pattern of prevalent dengue serotypes was observed over different time periods.
- The early phase of dengue infection often presents as undifferentiated fever, necessitating clinical suspicion for severe cases.
Conclusions:
- Effective management of dengue infection relies on prompt clinical suspicion and supportive care, including judicious fluid resuscitation.
- Addressing current knowledge gaps through targeted future research is crucial for improving dengue control strategies in Malaysia.
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