Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Liposomes as delivery vectors for nucleic acid mimics into <i>Escherichia coli</i>: effect of composition and functionalization.

Frontiers in bioengineering and biotechnology·2026

Same author

Biofouling in hospital greywater systems: Implications for public health and antimicrobial resistance.

Journal of environmental management·2026

Same author

Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond.

The journal of headache and pain·2026

Same author

New Disinfectant for Greywater Systems: Evaluation of Antibacterial Activity.

The Journal of hospital infection·2025

Same author

Nucleic Acid Lateral Flow Assays - A Review on Oligonucleotide-Based Methods.

Critical reviews in analytical chemistry·2025

Same author

Vapor phase of white thyme essential oil: effect on Candida albicans and preservation of Lactobacillus species in the context of vulvovaginal candidiasis.

BMC complementary medicine and therapies·2025

Search research articles

Related Experiment Video

Updated: Apr 20, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Caffeic acid loading wound dressing: physicochemical and biological characterization.

Eva Pinho¹, Mariana Henriques, Graça Soares

¹CEB, Centre for Biological Engineering, LIBRO -Laboratório de Investigação em Biofilmes RosárioOliveira, University of Minho, Campus Gualtar,4710-057 Braga, Portugal.

Therapeutic Delivery

|November 25, 2014

Summary

This summary is machine-generated.

New cyclodextrin-based hydrogels effectively deliver caffeic acid for wound infections. These novel wound dressings maintain the antibacterial properties of caffeic acid, offering a promising treatment for infected wounds.

More Related Videos

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

Related Experiment Videos

Last Updated: Apr 20, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

Area of Science:

Biomaterials Science
Pharmaceutical Technology
Wound Healing Research

Background:

Caffeic acid exhibits antibacterial activity against common wound pathogens.
Poor solubility and stability limit caffeic acid's pharmaceutical applications.
Cyclodextrin complexation can enhance caffeic acid's physicochemical properties.

Purpose of the Study:

To develop cyclodextrin-based hydrogels for controlled caffeic acid delivery.
To create an antibacterial wound dressing utilizing caffeic acid-loaded hydrogels.
To evaluate the potential of these hydrogels in treating wound infections.

Main Methods:

Preparation of hydrogels via direct crosslinking of cyclodextrins (β-cyclodextrin or hydroxypropyl-β-cyclodextrin) with 1,4-butanediol diglycidyl ether.
Incorporation of hydroxypropyl methylcellulose during hydrogel synthesis.
Characterization of hydrogel physicochemical properties and drug delivery capabilities.

Main Results:

The synthesized hydrogels demonstrated favorable viscoelasticity and superabsorbency.
Hydrogels effectively retained and controlled the release of caffeic acid.
The antibacterial activity of caffeic acid was preserved within the hydrogel matrix.
Gel-β-cyclodextrin formulations showed particular suitability, maintaining efficacy on fibroblasts.

Conclusions:

Developed cyclodextrin-based hydrogels show potential as effective drug delivery systems.
These hydrogels can serve as advanced wound dressing devices.
The system offers a promising approach for treating wound infections with enhanced caffeic acid delivery.