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Published on: November 7, 2017
[Hyperuricemia and progression of chronic cardiorenal compromise]
Manuel A Virú-Loza1, Alaciel Melissa Palacios-Guillén1
1Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
Insights
Hyperuricemia, or high uric acid levels, is an independent risk factor for chronic kidney disease progression in patients with cardiorenal compromise. This finding highlights the importance of managing uric acid in this vulnerable population.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Chronic cardiorenal compromise (CCC) involves simultaneous chronic kidney disease (CKD) and chronic heart disease (CHD).
- Hyperuricemia is a common comorbidity in patients with cardiovascular and renal diseases.
Purpose of the Study:
- To investigate the association between hyperuricemia and the progression of chronic cardiorenal compromise (CCC).
- To identify independent predictors of CKD progression in patients with CCC.
Main Methods:
- Retrospective cohort study including 103 patients with CCC.
- CKD progression defined as a 50% estimated glomerular filtration rate reduction (MDRD-4).
- Hyperuricemia defined as basal uric acid levels ≥ 7 mg/dL.
Main Results:
- Basal hyperuricemia (HR 4.41) was an independent predictor of CKD progression.
- Systolic arterial pressure (SAP) during follow-up (HR 1.05) also predicted CKD progression.
- No studied variables were associated with CCC or CHD progression.
Conclusions:
- Hyperuricemia is an independent risk factor for CKD progression in patients with CCC.
- Managing hyperuricemia may be crucial for slowing CKD progression in this patient group.
Abstract:
In order to determine whether hyperuricemia is associated with the progression of chronic cardiorenal compromise (CCC), a retrospective cohort study was performed which included 103 patients in whom CCC was defined as the simultaneous presence of chronic kidney disease (CKD) and chronic heart disease (CHD). CKD progression was defined as a 50% reduction of glomerular filtration rate estimated by the MDRD-4 equation. Hyperuricemia was defined as basal levels of uric acid ≥ 7 mg/dL. None of the studied variables showed association with the progression of CCC or CHD. Independent predictors of CKD progression were basal hyperuricemia (HR 4.41, 95% CI: 1.02-18.94) and SAP in followup (HR 1.05, 95% CI: 1.01-1.09). We conclude that hyperuricemia is an independent risk factor for the progression of CKD in patients with CCC.
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