Transdermal innovations in diabetes management
Rekha Rao, Sheefali Mahant, Lovely Chhabra
1Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, 124-001, India. sn_mdu@rediffmail.com.
Current Diabetes Reviews
|November 25, 2014
Summary
Transdermal drug delivery offers a promising alternative for managing diabetes mellitus, overcoming limitations of conventional methods. This approach optimizes insulin and oral hypoglycemic agent delivery through the skin for improved diabetes pharmacotherapy.
Area of Science:
- Endocrinology and Pharmaceutical Sciences
- Focuses on glucose metabolism disorders and advanced drug delivery systems.
Background:
- Diabetes mellitus remains a significant global health challenge with unsatisfactory conventional treatments.
- Limitations of oral and parenteral routes necessitate exploring alternative drug delivery systems for diabetes management.
Observation:
- Transdermal drug delivery systems (TDDS) enable controlled drug release through the skin, achieving therapeutic concentrations.
- This method circumvents the adverse effects and inconvenience associated with traditional administration routes.
Findings:
- This review details transdermal approaches for insulin and oral hypoglycemic agents, including novel formulations like nanoparticles, microemulsions, and insulin pumps.
- Physical techniques such as iontophoresis and microneedles, alongside transdermal patches, are discussed for enhanced therapeutic performance.
Implications:
- Transdermal systems offer a patient-friendly and effective strategy to optimize diabetes pharmacotherapy.
- Future prospects, patented, and commercial antidiabetic formulations utilizing transdermal delivery are highlighted.
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