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Reference values for cardiopulmonary exercise testing in healthy adults: a systematic review
1University Utrecht and University Medical Center Utrecht, Master Clinical Health Sciences, Program in Physical Therapy Science, Utrecht, The Netherlands.
Reference values (RV) for cardiopulmonary exercise testing (CPET) are crucial for assessing exercise response normality. Due to diverse populations, no single RV set exists; labs must choose values reflecting their specific patient groups and testing methods.
Area of Science:
- Exercise Physiology
- Clinical Diagnostics
Background:
- Reference values (RV) are essential for interpreting cardiopulmonary exercise testing (CPET) results.
- Accurate RV are critical for clinical decision-making regarding patient exercise response normality.
Purpose of the Study:
- To systematically review existing literature on RV for CPET in healthy adults.
- To provide recommendations for the practical application of CPET RV.
Main Methods:
- Systematic literature searches were conducted in MEDLINE, EMBASE, and PEDro databases.
- The review covered studies published up to March 2014.
Main Results:
- 35 studies on CPET RV were identified from the last 30 years.
- No universal set of ideal RV was found due to significant population diversity.
- Data cannot be pooled into a single equation for all populations.
Conclusions:
- Each exercise laboratory must select RV sets that align with their specific population, equipment, and methodology.
- Tailored RV selection is necessary for accurate CPET interpretation.
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