Related Experiment Videos
Cystosarcoma phyllodes. Effective therapy with cisplatin and etoposide chemotherapy
G V Burton1, L L Hart, G S Leight
1Comprehensive Breast Clinic, Duke University Medical Center, Durham, North Carolina.
Cancer
|June 1, 1989
Summary
Cystosarcoma phyllodes, a rare breast cancer, showed promising results with cisplatin and etoposide chemotherapy and radiation therapy. Hormonal therapy was ineffective, suggesting functional hormone receptors may not be present.
Area of Science:
- Oncology
- Medical Research
Background:
- Cystosarcoma phyllodes is a rare breast neoplasm with a low metastatic rate.
- Conventional treatments like chemotherapy, radiation, and hormonal therapy are often reported as ineffective for this condition.
Observation:
- Three patients with cystosarcoma phyllodes were treated with a combination chemotherapy regimen of cisplatin and etoposide.
- Radiation therapy was administered to all three patients.
- Hormonal therapy was given to two patients who had positive hormone receptors.
Findings:
- Combination chemotherapy with cisplatin and etoposide provided effective palliation in two out of three patients.
- Radiation therapy was successful in controlling symptomatic metastasis in all three patients.
- Hormonal therapy proved ineffective in two patients, even with positive hormone receptors, suggesting a lack of functional receptors.
Implications:
- Chemotherapy and radiotherapy may offer more effective treatment options for cystosarcoma phyllodes than previously documented.
- Hormonal therapy appears to have no role in treating this neoplasm.
- The ineffectiveness of hormonal therapy suggests that functional hormone receptors may not be present in cystosarcoma phyllodes tumors.