Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

8.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.1K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.6K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.2K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.8K
1.8K
Abnormal Proliferation02:23

Abnormal Proliferation

5.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.5K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

10.0K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crosstalk in Alzheimer's-delirium nexus: Molecular mechanisms and therapeutic repurposing.

International review of neurobiology·2026
Same author

MedNLP-Hub: A knowledgebase platform for biomedical NLP tool discovery in clinical informatics.

International journal of medical informatics·2026
Same author

Role of Phenolic Nanocompounds in Inflammatory Disorders: Current View and Future Aspects.

Current pharmaceutical design·2026
Same author

Innovative diabetes mellitus treatment strategies: Mesenchymal stem cell-based therapy and its impact on pro- and anti-inflammatory cytokines modulation.

Journal of pharmaceutical analysis·2026
Same author

Augmenting large language models with clinical knowledge graph for personalized perioperative fluid therapy question answering.

PLOS digital health·2026
Same author

Modulating the Gut-Liver Axis: Anti-Inflammatory Mechanisms of Probiotics and Prebiotics in MASLD.

Probiotics and antimicrobial proteins·2026

Related Experiment Video

Updated: Apr 20, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

Key regulators in prostate cancer identified by co-expression module analysis.

Junfeng Jiang, Peilin Jia, Zhongming Zhao1

  • 1Center for Systems Biology, Soochow University, Jiangsu, China. zhongming.zhao@vanderbilt.edu.

BMC Genomics
|November 25, 2014
PubMed
Summary

This study identifies key gene co-expression modules and regulatory elements, including transcription factors and microRNAs, crucial for prostate cancer (PrCa) development. These findings offer new insights into the complex etiology of PrCa.

More Related Videos

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Related Experiment Videos

Last Updated: Apr 20, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • Prostate cancer (PrCa) is a leading global cancer in men.
  • The etiology of PrCa is poorly understood despite extensive gene investigation.
  • Replication of PrCa candidate genes and their biological functions remain challenging.

Purpose of the Study:

  • To identify key players in the prostate cancer system.
  • To reconstruct prostate cancer co-expressed gene modules within Gene Ontology (GO) functional sets.
  • To find conserved modules enriched with PrCa candidate genes.

Main Methods:

  • Reconstruction of PrCa co-expressed modules using Gene Ontology (GO) annotation (biological process, GO_BP).
  • Identification of conserved modules across two independent gene expression datasets.
  • Enrichment analysis of modules with PrCa candidate genes from eQTL, SCNA, mutation, and prognostic data.

Main Results:

  • 118 GO_BP terms and 55 conserved co-expression modules were identified.
  • Five modules were significantly enriched with PrCa candidate genes.
  • Two transcription factors (NFAT, SP1) and three microRNAs (hsa-miR-19a, hsa-miR-15a, hsa-miR-200b) were found critical for PrCa development.

Conclusions:

  • Genes with similar functions play roles in disease via co-expression.
  • Modules with different functions can be synergistically regulated by common genetic components like TFs and microRNAs.
  • This study provides a framework for understanding PrCa etiology through gene co-expression network analysis.