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Essential thrombocytosis accompanied by coagulation factor XII deficiency: a case report

Yan Wang1, Zunsong Wang1, Hong Li1

  • 1Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.

International Journal of Clinical and Experimental Medicine
|November 25, 2014
PubMed

Essential thrombocytosis (ET) is a type of myeloproliferative neoplasm with clinical manifestations of thrombosis and hemorrhage, the mechanisms of which remains unclear. Some researches indicated that ET is mainly related to the defect of platelet function and the abnormality of coagulation mechanism. A few reports showed that ET accompanied by acquired hemophilia. However, no evidence of ET with coagulation factor XII deficiency has been published. we here report a case of ET accompanied with coagulation factor XII deficiency, which had clinically significant bleeding tendency.

Keywords:
Essential thrombocytosiscoagulation factor XII deficiencymyeloproliferative diseasevon Willebrand disease

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