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Updated: Apr 20, 2026

Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope
Published on: February 28, 2019
Acoustic force spectroscopy
Gerrit Sitters1, Douwe Kamsma1, Gregor Thalhammer2
11] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
Abstract:
Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.
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