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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Unrenewable Cells00:50

Unrenewable Cells

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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Hearing01:31

Hearing

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When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
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Related Experiment Video

Updated: Apr 20, 2026

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Treating hearing disorders with cell and gene therapy.

Lisa N Gillespie, Rachael T Richardson, Bryony A Nayagam

    Journal of Neural Engineering
    |November 25, 2014
    PubMed
    Summary

    New cell and gene therapies offer hope for treating progressive hearing loss. These innovative approaches aim to protect auditory cells and regenerate lost function, addressing a critical unmet clinical need.

    Area of Science:

    • Otolaryngology
    • Regenerative Medicine
    • Genetics

    Background:

    • Hearing loss is a growing global health issue, exacerbated by aging populations.
    • Current therapeutic options for hearing loss are limited, highlighting an urgent need for novel treatments.
    • Progressive hearing loss presents an opportunity for interventions that can slow, halt, or reverse functional decline.

    Purpose of the Study:

    • To explore the potential of cell- and gene-based therapies for hearing loss treatment.
    • To investigate methods for protecting auditory sensory and neural cells from damage.
    • To examine the feasibility of replacing lost auditory cells using stem cell and gene therapy approaches.

    Main Methods:

    • Review of emerging cell- and gene-based therapeutic technologies.

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  • Analysis of strategies for protecting auditory cells from various insults.
  • Exploration of stem cell and gene therapy for auditory cell regeneration.

    • Main Results:

    • Cell- and gene-based therapies show promise in protecting auditory cells.
    • These therapies offer potential for replacing damaged or lost sensory and neural cells.
    • Clinical translation requires overcoming significant challenges.

    Conclusions:

    • Cell and gene therapies represent promising avenues for treating hearing loss.
    • Further research and development are crucial for clinical application.
    • Addressing the challenges in clinical translation is key to realizing therapeutic potential.