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Cardiovascular disease prevalence and relevance in haemophilia: a scoping review

I Rizwan1, L Minuk2, S Jackson3

  • 1Clinical Epidemiology and Biostatistics, McMaster University, Hamilton.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|November 26, 2014
PubMed

Insights

Cardiovascular disease (CVD) risk in patients with haemophilia is rising with increased longevity. However, research is conflicting on whether haemophilia protects against CVD or if aging PWH experience more events.

Area of Science:

  • Hematology
  • Cardiology
  • Public Health

Background:

  • Patients with haemophilia (PWH) are living longer due to improved treatments.
  • Increased longevity in PWH raises concerns about age-related cardiovascular disease (CVD) risk.
  • The shift in comorbidities necessitates evaluating the care model for aging PWH.

Purpose of the Study:

  • To assess the robustness of publications on CVD and haemophilia.
  • To determine if PWH longevity and associated CVD risk factors lead to CVD events.
  • To evaluate the need for expanded care for aging PWH.

Main Methods:

  • A scoping review was conducted.
  • 30 articles were selected and organized by publication date.
  • A citation matrix identified primary research articles on CVD risk factors in PWH.

Main Results:

  • Four of 14 original articles suggested a protective effect of haemophilia against CVD.
  • Twelve articles found similar CVD prevalence in PWH compared to the general population.
  • Seven articles reported a different CVD prevalence in the aging haemophilia population, indicating conflicting evidence.

Conclusions:

  • Existing literature provides conflicting evidence on whether haemophilia confers a protective effect against CVD.
  • The scoping review could not definitively conclude if PWH longevity and associated CVD risk factors lead to CVD events due to inconsistent findings in the assessed articles.

Keywords:
ageingcardiovascular diseasehaemophilialife expectancy

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