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Updated: Aug 18, 2026

Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice
Published on: September 17, 2015
[Effect of liposomes on the adrenoreactivity of the papillary muscle]
Abstract:
Unloaded phosphatidylcholine-cholesterol liposomes enhanced the affinity of adrenoreactive system of the rat heart muscle with the ligands and altered the degree of adrenoreceptors' negative cooperativity. The radioligand analysis with 3H-dihydroalprenolol revealed that the liposomes altered kinetic properties of sarcolemma's receptors as revealed by the enhancement of affinity with the marker, decreasing of maximal specific binding and augmentation of the degree of receptors' negative cooperativity.
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