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Intraocular Ossification in the GSP/pe Chicken With Imperfect Albinism.
K Shibuya1, K Kinoshita2, M Mizutani2
1Research and Development Department, Nippon Institute for Biological Science, Ome, Tokyo, Japan k_shibuya@nibs.or.jp.
Veterinary Pathology
|November 26, 2014
Summary
Blindness in GSP/pe chickens is linked to intraocular bone formation. This study investigates the development of bone within the eye, potentially originating from the retinal pigment epithelium (RPE) in this albino strain.
Area of Science:
- Ophthalmology
- Genetics
- Histology
Background:
- The GSP/pe chicken is an imperfect albino strain.
- Aged GSP/pe chickens exhibit blindness, ocular enlargement, and opaque lenses.
Purpose of the Study:
- To investigate the histopathology of ocular tissues in aged GSP/pe chickens.
- To determine the origin of intraocular osseous tissue in this strain.
Main Methods:
- Histologic examination of affected eyes from 52-week-old GSP/pe chickens.
- Decalcification of ocular tissues to facilitate sectioning.
- Microscopic analysis of intraocular structures.
Main Results:
- Intraocular osseous tissue was found to occupy a significant portion of the posterior chamber.
- Osseous tissue developed adjacent to the choroid, with absence of retinal pigment epithelium (RPE).
- Degenerate neuronal retina, deformed irises, ciliary bodies, and severe cataracts were observed.
Conclusions:
- Intraocular bone formation is a key feature of ocular pathology in aged GSP/pe chickens.
- The RPE is a potential source of the intraocular osseous tissue in this hereditary condition.
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