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Updated: Apr 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Papillon-Lefèvre syndrome: review of imaging findings and current literature
Jean Jose1, Kyle Bartlett1, Christopher Salgado1
1Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida (JJ, NMG)University of Miami Miller School of Medicine, Miami, Florida (KB)Department of Plastic Surgery, University of Miami Miller School of Medicine, Miami, Florida (CS)Department of Radiology, Jackson Memorial Medical Center, Miami, Florida (NMG).
Abstract:
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive condition that causes palmoplantar keratoderma and premature exfoliation of primary and secondary dentition. There are several diseases that can mimic PLS, and it is estimated that the disease is far more prevalent than documented but may either be misdiagnosed or not acknowledged. Radiological exams can provide important clues to differentiate between these syndromes and make an accurate diagnosis.
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