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Updated: Apr 20, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two new triterpenoid saponins obtained by microbial hydrolysis with Alternaria alternata AS 3.6872
Li-Hua Mu1, Yong-Jie Gu, Bai-Ping Ma
1a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
Abstract:
Compound 1, a triterpenoid saponin from Ardisia gigantifolia Stapf showing potential anti-tumour activity, was hydrolysed into two deglycosyl derivatives (2 and 3) by Alternaria alternata AS 3.6872. Both these derivatives are new compounds. Their structures were elucidated on the basis of 1D, 2D NMR, HR-ESI-MS and optical rotation spectral data. Compounds 1-3 were evaluated for their cytotoxicity against human hepatocellular carcinoma and normal liver cells by Cell Counting Kit 8 colorimetric assay.
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