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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Related Experiment Video

Updated: Apr 20, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Prostate cancer epigenome.

Swathi Chinaranagari1, Pankaj Sharma, Nathan J Bowen

  • 1Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 26, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetic changes are crucial in prostate cancer development and progression, influenced by age, ancestry, and environment. Next-generation sequencing helps uncover these genomic epigenetic alterations.

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Area of Science:

  • Oncology
  • Genetics
  • Epigenetics

Background:

  • Prostate cancer presents a significant health challenge, particularly in aging populations.
  • Its molecular mechanisms are complex and varied.
  • Epigenetic modifications are emerging as key drivers of prostate cancer initiation and progression.

Purpose of the Study:

  • To review the global epigenetic landscape in prostate cancer.
  • To highlight the role of epigenetics in relation to major risk factors (age, ancestry, environment).
  • To explore how epigenetic alterations affect critical pathways like the androgen receptor.

Main Methods:

  • Focus on a global epigenetic perspective.
  • Utilize next-generation sequencing (NGS) technologies.
  • Interrogate epigenetic changes within the prostate cancer genome.

Main Results:

  • Epigenetic alterations are widespread in prostate cancer.
  • Key risk factors for prostate cancer are linked to epigenetic modifications.
  • The androgen receptor pathway is significantly impacted by epigenetic changes.

Conclusions:

  • Epigenetics plays a vital role in prostate cancer etiology and advancement.
  • Further research into epigenetic mechanisms is essential for understanding prostate cancer.
  • Advanced sequencing techniques are powerful tools for studying prostate cancer epigenetics.