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Methylation profile landscape in mesothelioma: possible implications in early detection, disease progression, and
Xinbo Zhang1, Naimei Tang, Arun K Rishi
1Department of Oncology, Karmanos Cancer Institute, Wayne State University and John D. Dingell VA Medical Center, Detroit, MI, 48201, USA.
Abstract:
Malignant Pleural Mesothelioma (MPM) is an aggressive malignancy of the pleura associated with asbestos exposure. Incidence of MPM is expected to increase over the course of next decade in both Europe and the developing countries. Although significant progress has been made in terms of etiology and pathogenesis of this disease, currently available therapeutic options have not significantly improved the survival outcome of patients on standard chemotherapeutic regimens. Integrity of the cellular DNA is often altered in many cancers. Understanding of the molecular mechanisms that regulate cellular DNA alterations to facilitate cancer initiation and development has potential to allow better design of cancer cell inhibitory strategies. In this context, there is a need to explore the gamut of "omics" strategies to provide a comprehensive epigenetics profile for MPM. This chapter discusses the functional genomics and epigenetic patterns observed by various investigators studying MPM patient populations on global fronts, and attempts to present a holistic approach in combating this insidious disease. Here we provide investigators in this field with novel insights and methodologies used in other types of cancers that might have profound impact in the early detection, prognosis and potential therapeutic strategies for MPM.
Insights
Malignant pleural mesothelioma (MPM) is an aggressive cancer linked to asbestos. New "omics" strategies offer insights into its epigenetics for better detection and treatment.
Area of Science:
- Oncology
- Genetics
- Epigenetics
Background:
- Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure.
- Current therapeutic options offer limited improvement in patient survival outcomes.
- Increasing incidence of MPM is projected globally in the coming decade.
Purpose of the Study:
- To explore "omics" strategies for a comprehensive epigenetics profile of MPM.
- To present a holistic approach for combating MPM based on functional genomics and epigenetic patterns.
- To provide novel insights and methodologies for early detection, prognosis, and therapeutic strategies.
Main Methods:
- Review of functional genomics and epigenetic patterns in MPM patient populations.
- Analysis of "omics" strategies applied to MPM research.
- Exploration of methodologies from other cancer types for potential MPM application.
Main Results:
- Understanding molecular mechanisms of DNA alterations is crucial for cancer development.
- Epigenetic profiling offers potential for improved MPM management.
- Novel insights into MPM pathogenesis and progression are emerging from omics studies.
Conclusions:
- Comprehensive epigenetics profiling using "omics" is essential for advancing MPM research.
- Translating findings from other cancers may yield significant improvements in MPM early detection, prognosis, and treatment.
- A holistic approach integrating functional genomics and epigenetics is key to combating MPM effectively.
