Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...

Structural Protein Function

Structural Protein Function

No description available

Cytoskeletal Linker Proteins - Plakins

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Mechanical Protein Functions

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.

Fruit Development, Structure, and Function

Fruit Development, Structure, and Function

Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Urolithin A: A Mitochondrial Remedy for the Anxious Mind.

Biological psychiatry·2026

Same author

A history of maternal separation drives systemic aging-associated signatures in middle-aged male rats.

Frontiers in cellular neuroscience·2026

Same author

Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI.

Neuron·2024

Same author

Acute immobilization stress evokes sexually dimorphic peripheral and hippocampal neuroimmune responses in adult rats.

Neuroscience letters·2022

Same author

Early Adversity and Accelerated Brain Aging: A Mini-Review.

Frontiers in molecular neuroscience·2022

Same author

Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior.

eNeuro·2022

Search research articles

Related Experiment Video

Updated: Feb 15, 2026

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

Versatile hemidesmosomal linker proteins: structure and function.

Pratik R Chaudhari¹, Milind M Vaidya²

¹Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, India.

Histology and Histopathology

|November 26, 2014

Summary

Hemidesmosome proteins BPAG1e and plectin link skin cells to the extracellular matrix. Mutations cause blistering, but these proteins also regulate cell movement and cytoskeleton dynamics.

More Related Videos

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Published on: November 21, 2010

Related Experiment Videos

Last Updated: Feb 15, 2026

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Published on: November 21, 2010

Area of Science:

Cell Biology
Dermatology
Biochemistry

Background:

Hemidesmosomes anchor basal epidermal cells to the extracellular matrix.
Key components include transmembrane proteins (α6β4 integrin, BP180, CD151) and cytoplasmic proteins (BPAG1e, plectin).
BPAG1e and plectin are plakin family proteins crucial for anchoring intermediate filaments (keratins).

Purpose of the Study:

To review the structural and signaling roles of hemidesmosomal linker proteins BPAG1e and plectin.
To highlight their function beyond anchoring, including roles in cell motility and cytoskeleton dynamics.
To discuss the implications of mutations in these proteins for skin blistering disorders.

Main Methods:

Literature review of recent reports and existing studies.
Analysis of molecular mechanisms underlying hemidesmosome assembly and function.
Examination of genetic mutations and their phenotypic consequences.

Main Results:

Mutations in BPAG1e and plectin cause severe skin blistering diseases.
BPAG1e and plectin are involved in regulating cell motility.
These proteins also play a role in cytoskeleton dynamics.

Conclusions:

BPAG1e and plectin are essential for hemidesmosome structural integrity.
These linker proteins have critical signaling functions influencing cell behavior.
Understanding their dual roles is vital for treating blistering disorders.