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Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus
S Ishihara1, A Tawa, K Yumura-Yagi
1Department of Pediatrics, Osaka University Hospital.
Japanese Journal of Cancer Research : Gann
|February 1, 1989
Abstract:
A 10-year-old boy with chronic active Epstein-Barr virus (EBV) infection developed T-cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3+, CD4+ and HLA-DR+. The genomic DNAs from these cells demonstrated two rearranged T-cell receptor beta-chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T-cell lymphoproliferation.