Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Targeted Cancer Therapies

Targeted Cancer Therapies

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Machine learning-based prediction of mortality and hospitalization in diabetic patients with heart failure with preserved ejection fraction: the GUARDIAN-P risk score.

European heart journal. Digital health·2026

Same author

Clinical Impact of Initial Low Molecular Weight Heparin Use in Hospitalised Patients with Venous Thromboembolism Treated with Direct Oral Anticoagulants: A Propensity Score Matched Study.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026

Same author

Doxorubicin-Induced Cardiotoxicity in Breast Cancer: Mechanistic Pathways, Pharmacogenomic Modifiers, and Translational Strategies.

Cardiovascular toxicology·2026

Same author

Lymph-vascular invasion affects the selection of time interval between surgery and postoperative chemotherapy in colon cancer.

Current problems in surgery·2026

Same author

SARS-CoV-2 Spike Protein-Mediated Cardiac Dysfunction: Structural Abnormalities, Impaired Calcium Dynamics, and Gene Expression Changes in Human Stem Cell-Derived Cardiomyocytes.

Journal of medical virology·2026

Same author

Association between adherence to a healthy lifestyle and firefighters' depression and posttraumatic stress disorder in Taiwan: A longitudinal, prospective cohort study.

Preventive medicine reports·2025

Search research articles

Related Experiment Video

Updated: Apr 20, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Targeted alpha anticancer therapies: update and future prospects.

Barry J Allen¹, Chen-Yu Huang², Raymond A Clarke³

¹Faculty of Physics, University of Sydney, Sydney, NSW, Australia ; Faculty of Medicine, Ingham Institute, University of Western Sydney, Liverpool, NSW, Australia.

Biologics : Targets & Therapy

|November 26, 2014

Summary

This summary is machine-generated.

Targeted alpha therapy (TAT) uses alpha-emitting radionuclides to precisely kill cancer cells, minimizing damage to healthy tissues. This review explores TAT safety, efficacy, and future directions for various cancers.

Keywords:

C595 J591 PAI2 bevacizumab biodosimetry cancer metastases microdosimetry mutagenesis tumors

More Related Videos

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Experiment Videos

Last Updated: Apr 20, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

Oncology
Nuclear Medicine
Radiochemistry

Background:

Targeted alpha therapy (TAT) is an innovative cancer treatment utilizing alpha-emitting radionuclides.
Preclinical and clinical studies demonstrate TAT's potential to selectively eliminate cancer cells with reduced toxicity.
Radium-223 dichloride (RaCl2) is an FDA-approved alpha emitter for prostate cancer bone metastases.

Purpose of the Study:

To review the safety and tolerance of targeted alpha therapy.
To evaluate the clinical efficacy of TAT for various solid tumors and hematological malignancies.
To discuss key research aspects, including targeting vectors and dosimetry, and propose future directions.

Main Methods:

Review of preclinical research and clinical trials on targeted alpha therapy.
Analysis of safety and tolerance data, including microdosimetry, biodosimetry, and mutagenesis.
Examination of clinical outcomes for specific cancer types treated with TAT.

Main Results:

Alpha-emitting isotopes like Actinium-225, Bismuth-223, and Thorium-227 are used with targeting vectors (e.g., monoclonal antibodies).
TAT demonstrates potential for tumor anti-vascular (TAVAT) effects, enhancing efficacy.
Clinical trials show promise for TAT in treating neuroendocrine tumors, leukemia, glioma, melanoma, lymphoma, and prostate cancer.

Conclusions:

Targeted alpha therapy offers a promising approach for cancer treatment with a favorable safety profile.
Further research into dosimetry, targeting strategies, and combination therapies can optimize TAT efficacy.
TAT holds significant potential for improving patient outcomes across a range of malignancies.