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Conflicting pathology reports: a diagnostic dilemma
Tal Shahar1, Uri Rozovski, Yuval Shapira
1Departments of 1 Neurosurgery.
Journal of Neurosurgery
|November 26, 2014
Summary
Discordant brain lesion pathology reports can arise from errors. Short tandem repeat (STR) analysis revealed two different individuals
Area of Science:
- Neuropathology
- Molecular Diagnostics
- Oncology
Background:
- Differential diagnosis of brain lesions with discordant pathology reports is challenging.
- Potential causes include collision tumors, metaplastic changes, or specimen processing errors.
Observation:
- A case involving a 47-year-old male smoker with two discordant brain biopsy reports.
- Initial biopsy suggested metastatic small cell carcinoma; subsequent biopsy indicated glioblastoma.
Findings:
- Short tandem repeat (STR) analysis was performed on both specimens and patient DNA.
- STR analysis demonstrated that the two biopsy specimens originated from different individuals.
Implications:
- STR analysis is a valuable tool for resolving discrepancies in discordant pathology reports.
- Detecting allele imbalance or loss of heterozygosity aids in accurate patient diagnosis and treatment planning.
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