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Acid-base titrations using microfluidic paper-based analytical devices.

Shingo Karita1, Takashi Kaneta

  • 1Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University , Okayama, 700-8530 Japan.

Analytical Chemistry
|November 26, 2014
PubMed
Summary

This study presents a novel microfluidic paper-based analytical device (μPAD) for rapid and simple acid-base titrations. The μPAD enables quick, instrument-free concentration determination of solutions like sodium hydroxide.

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Traditional acid-base titrations can be time-consuming and require specialized equipment.
  • There is a need for rapid, portable, and cost-effective analytical methods for chemical analysis.

Purpose of the Study:

  • To develop and validate a microfluidic paper-based analytical device (μPAD) for efficient acid-base titrations.
  • To demonstrate the μPAD's capability for determining the concentration of various acidic and basic solutions.

Main Methods:

  • Fabrication of the μPAD using wax printing with integrated reaction and detection reservoirs.
  • Utilizing potassium hydrogen phthalate (KHPth) as a primary standard for sodium hydroxide (NaOH) titration.
  • Visual endpoint determination based on color change in phenolphthalein-containing detection reservoirs.

Main Results:

  • The μPAD achieved rapid (within 1 min) and accurate acid-base titrations without instrumentation.
  • The device successfully determined NaOH concentrations across a wide range (0.01 to 1 M) and was applicable to various acids and ammonia.
  • Field analysis of acidic hot spring water using the μPAD showed excellent agreement with classic titration methods.

Conclusions:

  • The developed μPAD offers a simple, rapid, and portable platform for acid-base titrations.
  • This technology has potential applications in field testing and resource-limited settings.
  • The μPAD demonstrates good stability under appropriate storage conditions.