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The role of Toll-like receptor polymorphisms in acute pancreatitis occurrence and severity

Ana M Matas-Cobos1, Eduardo Redondo-Cerezo, Carlos Alegría-Motte

  • 1From the Departments of *Gastroenterology and Hepatology, and †Immunology, Virgen de las Nieves University Hospital; and ‡Department of Medicine, University of Granada, Granada, Spain.

Pancreas
|November 26, 2014
PubMed
Abstract

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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