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A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2
Benhua Wang1, Jiangli Fan, Xianwu Wang
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. fanjl@dlut.edu.cn.
Chemical Communications (Cambridge, England)
|November 27, 2014
Abstract:
The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
