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Related Concept Videos

Genomics02:02

Genomics

42.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genome Size and the Evolution of New Genes03:21

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Genomic resources notes accepted 1 August 2014-30 September 2014.

, Wolfgang Arthofer, B L Banbury

    Molecular Ecology Resources
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    PubMed
    Summary
    This summary is machine-generated.

    This study releases valuable genomic and transcriptomic data for several species, including cone snails, mosquitoes, flies, toads, and lizards, aiding future research in evolutionary biology and conservation genetics.

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    Area of Science:

    • Genomics
    • Transcriptomics
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Genomic and transcriptomic data are crucial for understanding species evolution and diversity.
    • Publicly available datasets facilitate comparative genomics and population studies.

    Purpose of the Study:

    • To document the public availability of novel genomic and transcriptomic datasets.
    • To provide sequence data, assembly, annotation, and SNP markers for diverse species.

    Main Methods:

    • Transcriptome sequencing and analysis
    • Single nucleotide polymorphism (SNP) marker development
    • Genomic sequence assembly and annotation

    Main Results:

    • Public release of transcriptome data, assembly, annotation, and SNPs for *Conus miliaris* (cone snail).
    • Development of SNP markers for *Culex pipiens* (mosquito) biotypes.
    • Public release of transcriptome data, assembly, annotation, and SNPs for *Rhinella marina* and *R. schneideri* (toads).
    • Availability of partial genomic sequence assembly and annotation for 35 *Sceloporus* (spiny lizard) species.

    Conclusions:

    • The released datasets represent a significant contribution to public genomic resources.
    • These data will support research in population genetics, evolutionary studies, and conservation efforts across multiple taxa.