Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.7K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.5K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.5K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

6.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.9K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

2
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preterm Delivery; Who Is at Risk?

Journal of clinical medicine·2021
Same author

Association Between Mode of Delivery of the Breech Fetus and Hospitalizations Due to Inflammatory Bowel Disease During Childhood.

Journal of clinical gastroenterology·2021
Same author

Maternal prenatal smoking and long-term gastrointestinal morbidity of the offspring: A population-based cohort analysis.

Reproductive toxicology (Elmsford, N.Y.)·2021
Same author

Hospitalizations Among Chernobyl-Exposed Immigrants to the Negev of Israel, 1992-2017: A Historical Follow-Up Study.

Journal of immigrant and minority health·2021
Same author

Condensation: A Retrospective Cohort Study to Investigate the Association Between Maternal Pre-pregnancy Obesity and Childhood Respiratory Disease.

Maternal and child health journal·2021
Same author

Can We Predict Preterm Delivery Based on the Previous Pregnancy?

Journal of clinical medicine·2021

Related Experiment Video

Updated: Apr 20, 2026

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature
10:07

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature

Published on: December 26, 2017

14.3K

Treating diabetes during pregnancy.

Jamie Klein1, Ron Charach, Eyal Sheiner

  • 1Ben-Gurion University of the Negev, Soroka University Medical Center, Department of Obstetrics and Gynecology, Faculty of Health Sciences , POB 151, Beer Sheva 84101 , Israel sheiner@bgu.ac.il.

Expert Opinion on Pharmacotherapy
|November 27, 2014
PubMed
Summary

Gestational diabetes mellitus (GDM) management involves a stepwise approach, starting with diet and exercise. Pharmacological treatments, including newer anti-hyperglycemic agents, are considered when lifestyle changes fail, offering alternatives to insulin.

Keywords:
diagnostic criteriagestational diabetes mellitusglyburideinsulin analogsmetforminpharmacotherapy

More Related Videos

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

1.5K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.5K

Related Experiment Videos

Last Updated: Apr 20, 2026

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature
10:07

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature

Published on: December 26, 2017

14.3K
Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

1.5K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.5K

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Pharmacology

Background:

  • Gestational diabetes mellitus (GDM) prevalence is increasing, affecting 3-5% of US pregnancies.
  • GDM is linked to adverse perinatal and maternal outcomes, underscoring the need for early diagnosis and treatment.
  • Timely GDM intervention prevents complications like macrosomia and obstetric issues.

Purpose of the Study:

  • To review the importance of GDM treatment and available glycemic control interventions.
  • To present the latest evidence on pharmacological treatments, focusing on anti-hyperglycemic agents.
  • To guide the timing, dosage, and selection of pharmacological agents for GDM.

Main Methods:

  • Literature review of GDM treatment strategies.
  • Analysis of current evidence on pharmacological interventions for glycemic control.
  • Evaluation of anti-hyperglycemic agents in GDM management.

Main Results:

  • A stepwise approach, starting with diet and exercise, is recommended for GDM treatment.
  • Pharmacological interventions are necessary when lifestyle modifications are insufficient.
  • Insulin remains a primary GDM treatment, but anti-hyperglycemic agents like glyburide and metformin are gaining traction.

Conclusions:

  • Anti-hyperglycemic agents offer patient-friendly alternatives to insulin, requiring less frequent monitoring and no injections.
  • Consideration of glyburide and metformin as first-line pharmacological treatments for GDM is warranted.
  • Further research is needed on long-acting insulins, other anti-hyperglycemic agents, and personalized GDM treatment strategies.