The physical properties and ion release of CPP-ACP-modified calcium silicate-based cements

Area of Science:

• Dental Materials Science
• Biomaterials Engineering
• Calcium Silicate Cements

Background:

• Calcium silicate-based cements (CSCs) are widely used in dentistry.
• Investigating modifications to enhance CSC properties is crucial for clinical applications.
• Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is a bioactive agent with potential benefits.

Purpose of the Study:

• To evaluate the impact of CPP-ACP on the physical properties and ion release of CSCs.
• To compare modified CSCs with a trial MTA and commercial CSCs (Biodentine, Angelus MTA).

Main Methods:

• CSCs were modified with varying concentrations of CPP-ACP (0-3.0%).
• Physical properties (setting time, solubility, compressive strength, microhardness) were assessed.
• Ion release (calcium, phosphate) and pH were measured over 336 hours.

Main Results:

• CPP-ACP addition, up to 1.0% in Biodentine and 0.5% in others, improved Ca(2+) and Pi release.
• Biodentine exhibited superior early Ca(2+) release, shorter setting time, and better mechanical properties.
• Mechanical properties of Angelus MTA and trial MTA were comparable; all cements yielded alkaline solutions.

Conclusions:

• CPP-ACP can enhance ion release from CSCs without compromising mechanical integrity or solubility within specific concentration limits.
• Biodentine demonstrates favorable early ion release and mechanical characteristics.
• CPP-ACP incorporation may prolong CSC setting times.