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Related Concept Videos

Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

213
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
213
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

155
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

144
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
144
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

109
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
109
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

138
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

365
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Micropatterning and Assembly of 3D Microvessels
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Microengineered vascular systems for drug development.

Candice M Hovell1, Yoshitaka J Sei2, YongTae Kim3

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA.

Journal of Laboratory Automation
|November 27, 2014
PubMed
Summary
This summary is machine-generated.

Microengineered vascular systems offer advanced in vitro models for drug delivery research. These platforms improve the assessment of drug candidates across physiological barriers, particularly for the central nervous system and cardiovascular system.

Keywords:
fabricationlab on a chipmicrofluidicsmicrotechnologynanobiotechnanotechnology

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Microfluidics

Background:

  • Recent advances in microfabrication and biomaterials enable sophisticated in vitro models.
  • Physiologically relevant cellular components and functions are crucial for accurate drug assessment.
  • Microengineered vascular systems are vital for studying drug interactions with microvessel barriers.

Purpose of the Study:

  • To review advancements in microengineered vascular structures.
  • To emphasize the impact of these systems on drug delivery studies.
  • To examine models for drug delivery to the central nervous system and cardiovascular system.

Main Methods:

  • Review of current literature on microengineered vascular systems.
  • Analysis of microfabrication technologies and biomaterials used.
  • Focus on applications in drug delivery research, specifically for CNS and cardiovascular systems.

Main Results:

  • Development of in vitro platforms that mimic physiological conditions.
  • Enhanced assessment of drug candidates against microvessel barriers.
  • Specific models developed for central nervous system and cardiovascular drug delivery studies.

Conclusions:

  • Microengineered vascular systems represent a significant advancement for in vitro drug delivery research.
  • These platforms hold great potential for improving the efficiency and accuracy of drug candidate assessment.
  • Future development will focus on overcoming current challenges and expanding applications.