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Updated: Apr 20, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
[Poor health at an earlier age: frailty in people with intellectual disabilities]
1*Namens de onderzoeksgroep Gezond Ouder met een verstandelijke beperking (GOUD), waarvan de leden aan het eind van dit artikel staan vermeld.
Abstract:
A study with 1050 people over the age of 50 years with mild to severe intellectual disabilities showed that the health of this group declined at a much younger age than in the general population of the same age. The cardiovascular risk was often higher and depression and sleep disorders were more common in people aged over 50 years with intellectual disabilities, but these were often not diagnosed. Recognising the underlying causes and determining which approach to take to them require specialist knowledge. The accumulation of unfavourable factors from childhood may lead to people becoming frail at an earlier age, which in this population is predictive of a decline in health and independence and a high risk of death within 3 years. The prevalences of multimorbidity and polypharmacy in people over 50 with intellectual disabilities are comparable to those of the Dutch nursing home population. In order to maintain the health and independence of people with an intellectual disability for longer, an improvement in vocational training for carers, development of multidisciplinary guidelines, and enhancement of the quality and availability of outpatient clinics with intellectual disability specialists are required.
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