Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy
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Updated: Apr 20, 2026
An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
1a Laboratory for AIDS Vaccine Research & Development; Department of Surgery; Duke University Medical Center; Durham, NC USA.
Abstract:
This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.
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