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Updated: Apr 20, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
NICU bedside caregivers sustain process improvement and decrease incidence of bronchopulmonary dysplasia in infants <
Sara J Mola1, David J Annibale2, Carol L Wagner2
1Department of Pediatrics, Division of Neonatology, University of Maryland School of Medicine, Baltimore, Maryland smola@peds.umaryland.edu.
A respiratory care bundle initially reduced bronchopulmonary dysplasia (BPD) in premature infants. However, this improvement was not sustained long-term, highlighting challenges in maintaining gains for very low birthweight infants.
Area of Science:
- Neonatal Medicine
- Pediatric Respiratory Medicine
- Quality Improvement in Healthcare
Background:
- Investigated the sustained impact of a respiratory care bundle on bronchopulmonary dysplasia (BPD) incidence.
- Focused on infants less than 30 weeks gestation managed by bedside caregivers.
- Utilized the Neonatal Intensive Care Quality Improvement Collaborative (NIC/Q 2005).
Purpose of the Study:
- To determine if a respiratory care bundle leads to a sustained decrease in BPD.
- To assess the effectiveness of caregiver-driven interventions in neonatal intensive care.
Main Methods:
- Retrospective cohort study of infants born between 23 and 29 weeks + 6 days gestation.
- Exclusion criteria included congenital heart disease, lung anomalies, or death before intubation.
- Data analyzed across four distinct time periods (2002-2010).
Main Results:
- BPD incidence significantly decreased post-bundle implementation (T3 vs. T1), but this was not sustained (T4).
- BPD-free survival to discharge improved initially but also lacked sustained benefit.
- Reduced ventilator days and increased noninvasive CPAP use were observed, alongside increased surfactant and caffeine administration.
Conclusions:
- A nurse and respiratory therapist-led respiratory bundle effectively increased less invasive respiratory support.
- Despite process improvements, sustained reduction in BPD incidence in very low birthweight infants was not achieved.
- Challenges remain in maintaining long-term improvements in BPD rates.
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