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Related Experiment Video

Updated: Apr 20, 2026

Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion.

Dasharath M Patel¹, Sweeti P Patel¹, Chhagan N Patel¹

¹Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana, Gujarat, India.

International Journal of Pharmaceutical Investigation

|November 27, 2014

Summary

Domperidone ternary solid dispersion significantly enhanced drug dissolution and stability in fast-dissolving tablets. The optimized formulation proved stable under accelerated conditions, offering improved therapeutic potential.

Keywords:

Fast dissolving tablet fusion method gelucire 50/13 poloxamer 188 stability ternary solid dispersion

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Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Fast dissolving tablets (FDTs) are designed for rapid drug release.
Domperidone's dissolution and solid dispersion stability present formulation challenges.

Purpose of the Study:

To develop a domperidone ternary solid dispersion for enhanced dissolution and stability.
To incorporate this dispersion into a fast-dissolving tablet.

Main Methods:

Prepared binary and ternary solid dispersions using the fusion method.
Characterized dispersions using solubility, dissolution, DSC, FTIR, and XRD.
Formulated FDTs via direct compression and evaluated tablet properties.

Main Results:

Optimized ternary solid dispersion (domperidone: Gelucire 50/13: Poloxamer 188, 1:2:1.5) showed maximum dissolution.
Solid-state characterization confirmed solid dispersion formation.
Ternary dispersions exhibited superior stability over binary dispersions.
FDTs with 4% Crospovidone achieved 100% dissolution within 30 min.

Conclusions:

Ternary agents improve domperidone dissolution and solid dispersion stability.
The developed fast-dissolving tablet containing ternary solid dispersion is stable for one month under accelerated conditions.