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Association study of the SLITRK5 gene and Tourette syndrome
Kevin Zhang1, Yu Feng, Karen G Wigg
1aGenetics and Development Division bDivision of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network cProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Abstract:
Tourette syndrome (TS) and obsessive-compulsive disorder commonly occur together. Family studies indicate shared genetic risk factors. SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine. In this study, we tested the SLITRK5 gene as a candidate for TS in a family-based sample with 377 affected children. Using single nucleotide polymorphisms tagging the gene, we did not find any evidence supporting the association of TS and SLITRK5.
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