[Status of thrombocyte membranes and lipid peroxidation in patients with unstable stenocardia]

Platelet and plasma lipid peroxidation (LPO) activity, and possible effect of LPO products on platelet membrane structure were examined in patients with unstable angina, an acute form of coronary disease. All parameters of LPO were increased both in the platelets and the plasma. It was demonstrated by spinning probes that platelet membrane S degree of order was increased significantly, an evidence of increased microviscosity, in patients with unstable angina. There also was a positive correlation between the S value and the level of LPO products. It is suggested that membrane disorders, in which CHD-related platelet hyperreactivity is rooted, may in part be due to PLO activation in the platelets.