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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
748
Medical marijuana in neurology
Selim R Benbadis1, Juan Sanchez-Ramos, Ali Bozorg
1Department of Neurology, University of South Florida, Tampa, FL, USA.
Expert Review of Neurotherapeutics
|November 27, 2014
Summary
Cannabinoids, compounds from the Cannabis plant, show therapeutic potential for neurological conditions like multiple sclerosis and epilepsy. While generally safe, potential adverse effects and dependence require further research for broader medical use.
Area of Science:
- Neurology
- Pharmacology
Background:
- Cannabis constituents, cannabinoids, are being investigated for therapeutic applications in neurological diseases.
- Key cannabinoids include Δ(9)-tetrahydrocannabinol (psychoactive) and cannabidiol (neuroprotective).
Purpose of the Study:
- To review the current clinical evidence for the therapeutic use of cannabinoids in neurologic diseases.
- To summarize the safety and efficacy data, as well as adverse events associated with cannabinoid use.
Main Methods:
- Review of high-quality clinical trials and lower-level clinical evidence.
- Analysis of data regarding safety, efficacy, and adverse events.
Main Results:
- Clinical trials support cannabinoids for multiple sclerosis spasticity, opioid-refractory pain, glaucoma, and nausea/vomiting.
- Evidence suggests potential benefits for dystonia, tics, tremors, epilepsy, migraine, and weight loss.
- Common adverse events include weakness, mood changes, and dizziness; cardiovascular and pulmonary effects are also noted.
Conclusions:
- Cannabinoids may offer compassionate use options for severe neurologic diseases when standard therapies fail.
- Further high-quality clinical data are needed to expand the therapeutic applications of cannabinoids.
- Ongoing research is crucial for a comprehensive understanding of cannabinoid safety and efficacy.
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