[The influence of melatonin on lipid peroxidation and antioxidant enzymes activity during multiply repetitive stress...

It was established that the modeling of the repeated immobilization stress is accompanied by the increase of the content of lipid peroxidation metabolites and the decrease of antioxidant enzymes activity (superoxiddismutase and catalase) in both blood plasma and liver tissue. Intraperitoneal melatonin injections in the doses 0.2 or 1 mg/kg during 7 days cause the decrease of the content of lipid peroxidation metabolites in both blood plasma and liver tissue in animals after prolonged stress, as well as leads to the increase superoxiddismutase activity in both blood plasma and liver tissue in comparison with the control group. In liver tissue catalase activity increased after the melatonin application at both doses in comparison with control animals, but in plasma the same change was observed only after 1 mg/kg melatonin inject. The results of investigation confir- med the literature data about the antioxidant effects of melatonin and opened the perspectives of its using for the prevention of stress-induced organ injury.