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Electrodiagnostic evolution of carcinomatous sensory neuronopathy
P D Donofrio1, A G Alessi, J W Albers
1Department of Neurology, University of Michigan Medical Center, Ann Arbor.
Muscle & Nerve
|June 1, 1989
Summary
Sensory neuronopathy, a lung cancer complication, was studied. Electrophysiology showed progression from normal nerves to severe sensory loss and late motor issues.
Area of Science:
- Neurology
- Oncology
- Neurophysiology
Background:
- Sensory neuronopathy is a known paraneoplastic syndrome.
- Lung carcinoma is a common cause of sensory neuronopathy.
Observation:
- A patient with lung carcinoma developed sensory neuronopathy.
- Serial electrophysiologic studies tracked the condition's progression.
Findings:
- The study observed a transformation from normal peripheral nerve function.
- Early posterior root involvement progressed to absent sensory nerve function.
- Late-stage diffuse motor conduction abnormalities suggested disuse-related motor axon changes.
Implications:
- This case highlights the electrodiagnostic evolution of sensory neuronopathy in lung cancer.
- Understanding this progression aids in early diagnosis and management.
- Further research can explore the mechanisms of paraneoplastic sensory neuronopathy.