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Comparative study of conductometric glucose biosensor based on gold and on magnetic nanoparticles
Wided Nouira1, Abderrazak Maaref2, Hamid Elaissari3
1Université de Lyon, Institut des Sciences Analytiques: Université Claude Bernard, Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France; Laboratoire des Interfaces et Matériaux Avancés, Université de Monastir, Avenue de l'Environnement, 5019 Monastir, Tunisia. widednouira@yahoo.fr
Abstract:
The aim of this study was to show the feasibility and the performances of nanoparticle biosensing. A glucose conductometric biosensor was developed using two types of nanoparticles (gold and magnetic), glucose oxidase (GOD) being adsorbed on PAH (poly(allylamine hydrochloride)) modified nanoparticles, deposited on a planar interdigitated electrode (IDEs). The best sensitivities for glucose detection were obtained with magnetic nanoparticles (70 μM/mM and 3 μM of detection limit) compared to 45 μM/mM and 9 μM with gold nanoparticles and 30 μM/mM and 50 μM with GOD directly cross-linked on IDEs. When stored in phosphate buffer (20 mM, pH 7.3) at 4 °C, the biosensor showed good stability for more than 12 days.
