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Marius Stefan1, Viorel Melnig2, Daniela Pricop2

  • 1Department of Biology, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.

Materials Science & Engineering. C, Materials for Biological Applications
|November 28, 2014
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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