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Relation between preclinical atherosclerosis and venous thromboembolism in patients with thrombophilias -

O Auzký1, R Dembovská, J Mrázková

  • 1Laboratory for Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. auzky@seznam.cz.

Physiological Research
|November 28, 2014
PubMed

Insights

Patients with thrombophilia and a history of venous thromboembolism (VTE) did not show greater atherosclerosis progression than those without VTE history. Both groups experienced unfavorable changes in body mass index and blood pressure.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Vascular Biology

Background:

  • Preclinical atherosclerosis is a potential risk factor for venous thromboembolism (VTE).
  • Understanding the relationship between atherosclerosis progression and VTE history in thrombophilia patients is crucial.

Purpose of the Study:

  • To investigate the progression of preclinical atherosclerosis in patients with thrombophilia, comparing those with and without a history of VTE.
  • To assess changes in traditional atherosclerosis risk factors in these patient groups over time.

Main Methods:

  • A longitudinal study followed 96 patients with thrombophilia (51 with VTE history, 45 without).
  • Preclinical atherosclerosis was assessed using ultrasound and the Belcaro score.
  • Changes in body mass index, waist circumference, and blood pressure were monitored.

Main Results:

  • No significant change in preclinical atherosclerosis (Belcaro score) was observed in either group over a mean follow-up of 56 months.
  • Both groups showed a significant increase in body mass index and a non-significant increase in systolic blood pressure.
  • Waist circumference increased significantly only in patients without a history of VTE.

Conclusions:

  • Patients with thrombophilia and a history of VTE do not exhibit greater atherosclerosis progression or increased traditional risk factors compared to those without VTE history.
  • Both groups experienced unfavorable changes in body mass index, waist circumference, and blood pressure during the study period.

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